healthy glow

Photo Dynamic Therapy with Levulan^TM - (Aminolevulinic acid 20% - or "ALA")

WHAT IS PHOTODYNAMIC THERAPY?

Photodynamic Therapy (PDT) is a special treatment performed with a topical photosensitizing agent called Levulan (5-aminolevulinic acid or ALA) activated with the correct wavelength of light. This is also known as “ALA/PDT treatment”. These treatments remove sun damaged pre-cancerous zones and spots called actinic keratosis. Sun damage, fine lines, and blotchy pigmentation are also improved because of the positive effect of Levulan and the light treatment. ALA/PDT treatment also has the unique ability to minimize pores and reduce oil glands, effectively treating stubborn acne vulgaris, acne rosacea, and improve the appearance of some acne scars.

HOW MUCH IMPROVEMENT CAN I EXPECT?

Patients with severe sun damaged skin manifested by actinic keratosis, texture, and tone changes including mottled pigmentation and skin laxity may see excellent results. You may also see improvement of large pores and pitted acne scars. Active acne can improve dramatically.

HOW MANY TREATMENTS WILL IT TAKE TO SEE THE “BEST RESULTS”?

To achieve maximum improvement of pre-cancerous (actinic keratosis) sun damage, skin tone and texture, a series of three treatments 2-4 weeks apart is the most effective. Some patients with only actinic keratosis are happy with just one treatment. More treatments can be done at periodic intervals in the future to maintain the rejuvenated appearance of the skin.

WHAT ARE THE DISADVANTAGES?

Following PDT, the treated areas can appear red with some peeling for 2-7 days. Some patients (up to 10%) have an exuberant response to PDT, and experience marked redness of their skin. Temporary swelling of the lips and around your eyes can occur for a few days. Darker pigmented patches called liver spots can become temporarily darker and then peel off leaving normal skin. (This usually occurs over seven to ten days.) Repeat treatments may be necessary as PDT medicine is not an exact science.

WHAT ARE THE ADVANTAGES?

1. Easier for patients than repeated topical liquid nitrogen, Efudex (5FU), or Aldara because the side effects are minimal, rapid healing, and only 1-3 treatments required.

2. The ALA/PDT treatment at our clinic is painless verses liquid nitrogen, 5-FU, and Aldara.

3. Reduced scarring and improved cosmetic outcome compared with cautery, surgery and Efudex. Liquid nitrogen can leave white spots on your skin.

4. Levulan improves the whole facial area treated creating all one color, texture, and tone rather than just spot treating with liquid nitrogen, cautery and surgery. In summary, PDT matches the “Ideal treatment” for photodamaged skin:

• well tolerated (essentially painless)
• easily performed by a specialty clinic environment
• non-invasive (no needles or surgery required)
• excellent cosmetic outcome (particularly in cosmetic sensitive areas of the face)

WHAT PROTOCOL DO YOU FOLLOW?

For the best results, the Harris Clinic uses the following protocol for Levulan/Photo Dynamic treatments:

1. Cursory microdermabrasion (click here for information) to remove and exfoliate dead skin from the skin surface.  This enhances penetration of Levulan into the skin.
2. Acetone scrub - the skin to be treated is scrubbed with acetone - this is important to ensure no dirt or grease remains on the skin.  Dirt and grease will reduce the efficacy of the Levulan treatment.
3. Levulan application - the Clinic physician applies the Levulan to the area to be treated.  The solution remains on the skin for 1.25 to 1.5 hours (face) and up to 3.0 hours on the back.
4. Blu-U light activation:  The treated skin is exposed to Blu-U light (duration determined by Clinic physician).
5. Optional Intense Pulse Light (IPL) treatment is also considered if red or brown acne scarring is present.  The IPL treatment (560nm to 1200nm of visible light spectrum) works complementary to Blu-U (~400nm) to activate the Levulan medication for even better results.